The Poisson regression analysis revealed a significant association between selenium and high levels of MDA, IL-6 and TNF-α ( p< 0.05). Results: When plasma selenium and indicators of inflammation and oxidative stress were compared between groups, plasma selenium levels were significantly lower in the ICM group than in the control group (68.83874 vs 104.39775, p=0.02032), while indicators of inflammation such as tumour necrosis factor-alpha (TNF-α) (79.09773 vs 46.15634, p 0.05). Blood specimens were collected from subjects and serum levels of inflammatory and oxidative stress indicators and plasma levels of selenium were measured. Methods: This study included 119 subjects, 43 of whom were patients with ICM, and 76 were healthy controls. However, the role of inflammatory responses in ICM has received limited attention. The oxidative stress theory is the most accepted theory of selenium causing ischemic cardiomyopathy. *These authors contributed equally to this workĬorrespondence: Yuanhong Li, Cardiovascular Disease Center, Central Hospital of Tujia and Miao Autonomous Prefecture, Hubei University of Medicine, Shiyan, People’s Republic of China, Email īackground: Ischemic cardiomyopathy (ICM) with high morbidity and mortality is closely associated with an abnormal equilibrium of circulation selenium levels. Yinhua Luo, 1, * Xiaohong He, 2, * Linbo Hu, 3 Jinbo Zhao, 1 Ke Su, 1 Yuhua Lei, 1 Yuanhong Li 1ġCardiovascular Disease Center, Central Hospital of Tujia and Miao Autonomous Prefecture, Hubei University of Medicine, Shiyan, People’s Republic of China 2Centre for Disease Control and Prevention, Enshi Center for Disease Control and Prevention, Enshi Prefecture, People’s Republic of China 3Health Management Centre, Central Hospital of Tujia and Miao Autonomous Prefecture, Enshi Prefecture, People’s Republic of China
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